Product Pathways - Apoptosis
Alix (3A9) Mouse mAb #2171
|2171S||100 µl (10 western blots)||---||In Stock||---|
|2171||carrier free and custom formulation / quantity||email request|
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|W||1:1000||Human, Mouse, Rat, Monkey||Endogenous||95||Mouse IgG1|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting, IP=Immunoprecipitation
Specificity / Sensitivity
Alix (3A9) Mouse mAb detects endogenous levels of total Alix protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with full-length recombinant human Alix protein.
Alix, a phylogenetically conserved cytosolic scaffold protein, contains an N-terminal Bro1 domain, a coiled-coil region and a C-terminal proline-rich domain (1,2). Originally identified as an ALG-2 (apoptosis-linked gene 2)-interacting protein involved in programmed cell death (3,4), Alix also regulates many other cellular processes, such as endocytic membrane trafficking and cell adhesion through interactions with ESCRT (endosomal sorting complex required for transport) proteins, endophilins, and CIN85 (Cbl-interacting protein of 85 kDa) (5,6).
- Mattei, S. et al. (2006) Eur. J. Cell Biol. 85, 925-936.
- Odorizzi, G. (2006) J. Cell Sci. 119, 3025-3032.
- Vito, P. et al. (1999) J. Biol. Chem. 274, 1533-1540.
- Missotten, M. et al. (1999) Cell Death Differ. 6, 124-129.
- Katoh, K. et al. (2003) J. Biol. Chem. 278, 39104-39113.
- Sadoul, R. (2006) Biol. Cell 98, 69-77.
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