Product Pathways - Protein Stability
MMP-9 (G657) Antibody #2270
|2270S||100 µl (10 western blots)||---||In Stock||---|
|2270||carrier free and custom formulation / quantity||email request|
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Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting
Specificity / Sensitivity
MMP-9 (G657) Antibody detects full length (proenzyme, 92 kDa) human MMP-9.
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to a sequence based around amino acid residue Gly657 of human MMP-9. Antibodies are purified by protein A and peptide affinity chromatography.
The matrix metalloproteinases (MMPs) are a family of proteases that target many extracellular proteins including other proteases, growth factors, cell surface receptors, and adhesion molecules (1). Among the family members, MMP-2, MMP-3, MMP-7, and MMP-9 have been characterized as important factors for normal tissue remodeling during embryonic development, wound healing, tumor invasion, angiogenesis, carcinogenesis, and apoptosis (2-4). Research studies have shown that MMP activity correlates with cancer development (2). One mechanism of MMP regulation is transcriptional (5). Once synthesized, MMP exists as a latent proenzyme. Maximum MMP activity requires proteolytic cleavage to generate active MMPs by releasing the inhibitory propeptide domain from the full length protein (5).
- Zhu, T.N. et al. (2007) J Biol Chem 282, 14816-26. Applications: Western Blotting.
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For Research Use Only. Not For Use In Diagnostic Procedures.
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