Product Pathways - Metabolism
SCD1 (R347) Antibody #2283
|2283S||100 µl (10 western blots)||---||In Stock||---|
|2283||carrier free and custom formulation / quantity||email request|
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Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting, IF-IC=Immunofluorescence (Immunocytochemistry)
Species predicted to react based on 100% sequence homology: Human.
Specificity / Sensitivity
SCD1 (R347) Antibody detects endogenous levels of total SCD1 protein.
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding R347 of human SCD1. Antibodies are purified by protein A and peptide affinity chromatography.
Stearoyl-CoA desaturase 1 (SCD1) is a key lipogenic enzyme found in the endoplasmic reticulum that catalyzes the conversion of palmitoyl–CoA and stearoyl–CoA to palmitoleoyl–CoA (16:1) and oleoyl–CoA (18:1) (1-3). Palmitoleate and oleate are the major components of triglycerides, membrane phospholipids and cholesterol esters (1). SCD1-knockout mice show improved insulin sensitivity and reduced body fat (1). Disruption of SCD1 in mouse brown adipose tissue strengthens insulin signaling and results in increased translocation of Glut4 to plasma membrane and enhanced uptake of glucose (4). Furthermore, SCD1 is essential for the onset of diet-induced body weight gain (1) and insulin resistance in the liver (5).
- Ntambi, J.M. et al. (2002) Proc. Natl. Acad. Sci. USA 99, 11482-114866.
- Kato, H. et al. (2006) J. Cell. Sci. 119, 2342-2353.
- Ozols, J. (1997) Mol. Biol. Cell 8, 2281-2290.
- Rahman, S.M. et al. (2005) Am. J Physiol. Endocrinol. Metab. 288, E381-387.
- Gutiérrez-Juárez, R. et al. (2006) J. Clin. Invest. 116, 1686-1695.
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