Product Pathways - Lymphocyte Signaling
DRAK2 (33D7) Rabbit mAb #2294
|2294S||100 µl (10 western blots)||---||In Stock||---|
|2294||carrier free and custom formulation / quantity||email request|
Already purchased this product? Write a Review.
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting, IP=Immunoprecipitation, IHC-P=Immunohistochemistry (Paraffin), F=Flow Cytometry
Specificity / Sensitivity
DRAK2 (33D7) Rabbit mAb detects endogenous levels of total DRAK2 protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding
Asp315 of mouse DRAK2.
Western blot analysis of total cell lysates from BaF3 and mouse thymocytes, using DRAK2 (33D7) Rabbit mAb.
Immunohistochemical analysis of paraffin-embedded mouse thymus, using DRAK2 (33D7) Rabbit mAb.
Flow cytometric analysis of BaF3 cells, using DRAK2 (33D7) Rabbit mAb (blue) compared to a nonspecific negative control antibody (red).
DRAK2 (DAP kinase related apoptosis inducing protein kinase 2) is a member of the novel DAP (death associated protein) pro-apoptotic kinase family (1). Overexpression of DRAK2 in NIH/3T3 cells induces morphological changes associated with apoptosis, which are likely to occur in a p53-dependent manner (1,2). DRAK2 is preferentially expressed in lymphoid tissues and regulates the TCR activation threshold during thymocyte selection (3). Indeed, T cells from DRAK2(-/-) mice exhibit enhanced sensitivity to T cell receptor-mediated stimulation and have a reduced requirement for co-stimulation (4).
Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know!
For Research Use Only. Not For Use In Diagnostic Procedures.
Cell Signaling Technology® is a trademark of Cell Signaling Technology, Inc.
This antibody is developed, validated, and produced by CST using in part technology under license (granting certain rights including those under U.S. Patents No. 5,675,063 and 7,429,487) from Epitomics, Inc.