Product Pathways - Lymphocyte Signaling
Thioredoxin 1 Antibody (Mouse/Rat Preferred) #2298
|2298S||100 µl (10 western blots)||---||In Stock||---|
|2298||carrier free and custom formulation / quantity||email request|
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Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting
Specificity / Sensitivity
Thioredoxin 1 Antibody (Mouse/Rat Preferred) detects endogenous levels of total mouse and rat thioredoxin 1 protein.
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the sequence of mouse thioredoxin 1. Antibodies are purified by protein A and peptide affinity chromatography.
Thioredoxin is a small redox protein found in many eukaryotes and prokaryotes. A pair of cysteines within a highly conserved, active site sequence can be oxidized to form a disulfide bond that is then reduced by thioredoxin reductase (1). Multiple forms of thioredoxin have been identified, including cytosolic thioredoxin 1 (TRX1) and mitochondrial thioredoxin 2 (TRX2). Thioredoxin participates in many cellular processes including redox signaling, response to oxidative stress and protein reduction (1). A potential role of thioredoxin in human disorders such as cancer, aging and heart disease is currently under investigation (2). Thioredoxin can play a key role in cancer progression, as it acts as a negative regulator of the proapoptotic kinase ASK1 (3). Changes in thioredoxin expression have been associated with meningococcal septic shock and acute lung injury (4,5).
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For Research Use Only. Not For Use In Diagnostic Procedures.
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