Cell Signaling Technology

Product Pathways - Metabolism

C/EBPδ Antibody #2318

Applications Reactivity Sensitivity MW (kDa) Source
W M R Endogenous 29 Rabbit

Applications Key:  W=Western Blotting
Reactivity Key:  M=Mouse  R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.

Protocols

Specificity / Sensitivity

C/EBPδ Antibody detects endogenous levels of total C/EBPδ protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the sequence of mouseC/EBPδ. Antibodies are purified by protein A and peptide affinity chromatography.

Western Blotting

Western Blotting

Western blot analysis of extract from differentiated 3T3-L1 cells, using C/EBPδ Antibody.

Background

CCAAT/enhancer-binding proteins (C/EBPs) are a family of transcription factors critical for cellular proliferation, differentiation, metabolism, inflammatory response and many other biological events (1,2). Six members of the family have been identified (C/EBPα, β, δ, γ, ε and ζ) and have been shown to distribute in a variety of tissues (1,2). C/EBPδ is highly expressed in adipose tissue, lung and intestine (2). C/EBPs play an important role in positively regulating adipogenesis (2,3) and C/EBPδ mRNA levels are enhanced during this process (3). C/EBPδ is also expressed in the mammalian nervous system (2) and has been shown to play an important role in long-term memory (4).

  1. Lekstrom-Himes, J. and Xanthopoulos, K.G. (1998) J Biol Chem 273, 28545-8.
  2. Ramji, D.P. and Foka, P. (2002) Biochem J 365, 561-75.
  3. Cao, Z. et al. (1991) Genes Dev 5, 1538-52.
  4. Taubenfeld, S.M. et al. (2001) J Neurosci 21, 84-91.

Application References

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Companion Products

For Research Use Only. Not For Use In Diagnostic Procedures.

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