Product Pathways - Cytoskeletal Signaling
Vav3 Antibody #2398
|2398S||100 µl (10 western blots)||---||In Stock||---|
|2398P||40 µl (4 western blots)||---||In Stock||---|
|2398||carrier free and custom formulation / quantity||email request|
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Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting
Specificity / Sensitivity
Vav3 Antibody detects endogenous levels of total Vav3 protein. The antibody does not cross-react with endogenous levels of other Vav family members.
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the central sequence of human Vav3. Antibodies are purified using protein A and peptide affinity chromatography.
Vav proteins belong to the Dbl family of guanine nucleotide exchange factors (GEFs) for Rho/Rac small GTPases. The three identified mammalian Vav proteins (Vav1, Vav2 and Vav3) differ in their expression. Vav1 is expressed only in hematopoietic cells and is involved in the formation of the immune synapse. Vav2 and Vav3 are more ubiquitously expressed. Vav proteins contain the Dbl homology domain, which confers GEF activity, as well as protein interaction domains that allow them to function in pathways regulating actin cytoskeleton organization (reviewed in 1). Phosphorylation stimulates the GEF activity of Vav protein towards Rho/Rac (2,3).
- Salhia, B. et al. (2008) Am J Pathol 173, 1828-38. Applications: Western Blotting.
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For Research Use Only. Not For Use In Diagnostic Procedures.
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