Product Pathways - Cytoskeletal Signaling
EML4 Antibody #2428
|2428S||100 µl (10 western blots)||---||In Stock||---|
|2428||carrier free and custom formulation / quantity||email request|
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Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting, IP=Immunoprecipitation, IF-IC=Immunofluorescence (Immunocytochemistry)
Specificity / Sensitivity
EML4 Antibody detects endogenous levels of total EML4 protein.
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Arg91 of human EML4. Antibodies are purified by protein A and peptide affinity chromatography.
Western blot analysis of extracts from MCF7, A431, SHSY5Y and HepG2 cells, using EML4 Antibody.
Echinoderm microtubule-associated protein-like 4 (EML4) is a 120 kDa microtubule-associated WD-repeat protein of the echinoderm microtubule-associated protein family (1). The expression of EML4 is necessary for correct intracellular microtubule network formation (2). EML4 protein expression is upregulated during mitosis and downregulated during the remaining cell cycle (1). During mitosis, EML4 is heavily phosphorylated and is associated with the mitotic spindle (2). The amino-terminal segment of EML4 is essential for microtubule association and function.
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For Research Use Only. Not For Use In Diagnostic Procedures.
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