Product Pathways - Tyrosine Kinase / Adaptors
VEGF Receptor 3 Antibody #2485
Reactivity Key: H=Human
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
Specificity / Sensitivity
VEGF Receptor 3 Antibody detects transfected levels of VEGFR-3. This antibody does not cross-react with VEGFR-1 and -2.
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Arg961 of human VEGFR-3. Antibodies are purified by protein A and peptide affinity chromatography.
Vascular endothelial growth factor receptor 3 (VEGFR3) is a 195 kDa membrane receptor tyrosine kinase. VEGF receptors are characterized by the presence of seven extracellular immunoglobulin (Ig)-like domains followed by a membrane-spanning domain and a conserved intracellular tyrosine kinase domain (1). VEGF receptor 3 expression is largely restricted to adult lymphatic endothelium and is thought to control lymphangiogenesis (1,2). Binding of VEGF-C/VEGF-D to VEGFR3 results in transphosphorylation of tyrosine residues in its intracellular domain, recruitment of signaling molecules and activation of ERK1/2 and Akt signaling cascades (1,3).
- Robinson, C.J. and Stringer, S.E. (2001) J. Cell Sci.114, 853-865.
- Valtola, R. et al. (1999) Am. J. Pathol. 154, 1381-1390.
- Saharinen, P. and Petrova, T.V. (2004) Ann. N.Y. Acad. Sci. 1014, 76-87.
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For Research Use Only. Not For Use In Diagnostic Procedures.