Product Pathways - DNA Damage
REDD1 Antibody #2516
Reactivity Key: H=Human
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
Specificity / Sensitivity
REDD1 Antibody detects transfected levels of REDD1 protein.
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide surrounding Asn60 of human REDD1. Antibodies are purified by peptide affinity chromatography.
REDD1 (REgulated in Development and DNA damage responses) expression is induced by hypoxia, cell stress, apoptosis and DNA damage. REDD1 is a transcriptional target of p53 and p63 following DNA damage, and links p63 to Ros (1). REDD1 functions as a negative regulator of mTOR in response to hypoxia in a tuberin-dependent manner (2). Depending on cell context, REDD1 can either be protecting or detrimental for cells under oxidative or ischemic stresses (3).
- Ellisen, L.W. et al. (2002) Mol Cell 10, 995-1005.
- Brugarolas, J. et al. (2004) Genes Dev 18, 2893-904.
- Shoshani, T. et al. (2002) Mol Cell Biol 22, 2283-93.
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For Research Use Only. Not For Use In Diagnostic Procedures.