Product Pathways - Neuroscience
α-Synuclein Antibody (IF Preferred) #2628
PhosphoSitePlus® protein, site, and accession data: SNCA
| Applications | Reactivity | Sensitivity | MW (kDa) | Source |
|---|---|---|---|---|
| W IF-F | H M R | Endogenous | 18 | Rabbit |
Applications Key:
W=Western Blotting
IF-F=Immunofluorescence (Frozen)
Reactivity Key:
H=Human
M=Mouse
R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
Protocols
Specificity / Sensitivity
α-Synuclein Antibody (IF Preferred) detects endogenous levels of total synuclein protein.
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the carboxy terminus of mouse synuclein. Antibodies are purified by peptide affinity chromatography.
Western Blotting
Western blot analysis of extracts from human cerebellum and mouse brain using α-Synuclein (IF Preferred) Antibody.
IF-F
Confocal immnofluorescent analysis of mouse brain using α-Synuclein Antibody (IF Preferred) (red) and Neurofilament-L (DA2) Mouse mAb #2835 (green). Blue pseudocolor = DRAQ5® #4084 (fluorescent DNA dye).
Background
α-Synuclein is a protein of 140-amino acids expressed abundantly in the brain. α-synuclein is also the main component of pathogenic Lewy bodies and Lewy neurites. Mutations of the α-synuclein gene have been linked to Parkinson disease (1).
Application References
Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know!
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This product is intended for research purposes only. The product is not intended to be used for therapeutic or diagnostic purposes in humans or animals.
