Product Pathways - Metabolism
Glucagon Antibody #2760
|IHC-P IHC-F IF-F||H M R||Endogenous||4||Rabbit|
Reactivity Key: H=Human M=Mouse R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
Specificity / Sensitivity
Glucagon Antibody detects endogenous levels of total glucagon protein.
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the sequence of human glucagon. Antibodies are purified by protein A and peptide affinity chromatography.
Immunohistochemical analysis of paraffin-embedded human pancreas, showing staining of α cells, using Glucagon Antibody.
Immunohistochemical analysis of paraffin-embedded mouse pancreas, showing staining of α cells, using Glucagon Antibody.
Glucose homeostasis is regulated by a variety of hormones including glucagon. Glucagon is synthesized as the precursor molecule proglucagon and is proteolytically processed to yield the mature peptide in α cells of the pancreatic islets. Glucagon causes the release of glucose from glycogen and stimulates gluconeogenesis in the liver (1,2).
- Hers, H.G. and Hue, L. (1983) Annu. Rev. Biochem. 52, 617-653.
- Granner, D. and Pilkis, S. (1990) J. Biol. Chem. 265, 10173-10176.
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For Research Use Only. Not For Use In Diagnostic Procedures.