Product Pathways - Translational Control
Ribosomal Protein L13a Antibody #2765
|W IP||H Mk||Endogenous||23||Rabbit|
Reactivity Key: H=Human Mk=Monkey
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
Specificity / Sensitivity
Ribosomal Protein L13a Antibody detects endogenous levels of total ribosomal protein L13a.
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the sequence of human ribosomal protein L13a. Antibodies are purified by peptide affinity chromatography.
Ribosomal protein L13a (RPL13a, 60S ribosomal protein L13a) is a member of the L13 ribosomal protein family and a structural component of the 60S ribosomal subunit (1). RPL13a appears to play an important role in transcript-specific translational silencing. Interferon-γ induces the phosphorylation of RPL13a and triggers the release of this protein from the 60S ribosomal subunit (2). Free RPL13a protein binds to the GAIT (interferon-γ-activated inhibitor of translation) complex at the 3'-UTR of ceruloplasmin (Cp) mRNA to repress Cp expression (2). RPL13a bound to the GAIT complex interacts with eIF4G, which prevents the recruitment of 43S ribosomal subunit and results in transcript-specific translation suppression (3).
- Higa, S. et al. (1999) Gene 240, 371-7.
- Mazumder, B. et al. (2003) Cell 115, 187-98.
- Kapasi, P. et al. (2007) Mol Cell 25, 113-26.
- Fuchs, G. et al. (2011) J Mol Biol 410, 118-30. Applications: Western Blotting
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For Research Use Only. Not For Use In Diagnostic Procedures.