Product Pathways - Translational Control
Grp75 Antibody #2816
|W IF-IC||H M R Mk||Endogenous||75||Rabbit|
Reactivity Key: H=Human M=Mouse R=Rat Mk=Monkey
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
Specificity / Sensitivity
Grp75 Antibody detects endogenous levels of total Grp75 protein.
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to a sequence of human Grp75. Antibodies are purified by peptide affinity chromatography.
Grp75, also known as mortalin, is a member of Hsp70 family of chaperone proteins that is not heat-inducible (1,2). This protein is essential for transporting many mitochondrial proteins from the cytoplasm to mitochondria (3). Grp75 inactivates the tumor suppressor p53 (4). Studies found that Grp75 is overexpressed in many tumor tissues and immortalized human cell lines, suggesting its role in the tumor formation (5). Grp75 is also implicated in cell aging, as its overexpression appears to prolong the life span of human fibroblasts (6).
- Kaul, S.C. et al. (1993) Biochem Biophys Res Commun 193, 348-55.
- Wadhwa, R. et al. (1993) J Biol Chem 268, 6615-21.
- Schneider, H.C. et al. (1994) Nature 371, 768-74.
- Wadhwa, R. et al. (1998) J Biol Chem 273, 29586-91.
- Wadhwa, R. et al. (2006) Int J Cancer 118, 2973-80.
- Kaul, S.C. et al. (2003) Exp Cell Res 286, 96-101.
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For Research Use Only. Not For Use In Diagnostic Procedures.