Product Pathways - Cytoskeletal Signaling
Vav2 (C64H2) Rabbit mAb #2848
|2848S||100 µl (10 western blots)||---||In Stock||---|
|2848P||40 µl (4 western blots)||---||In Stock||---|
|2848||carrier free and custom formulation / quantity||email request|
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|W||1:1000||Human, Monkey||Endogenous||100||Rabbit IgG|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting, IP=Immunoprecipitation
Specificity / Sensitivity
Vav2 (C64H2) Rabbit mAb detects endogenous levels of total Vav2 protein. The antibody is not expected to cross-react with Vav1 or Vav3 based on the sequence of the immunogenic peptide.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human Vav2.
Vav proteins belong to the Dbl family of guanine nucleotide exchange factors (GEFs) for Rho/Rac small GTPases. The three identified mammalian Vav proteins (Vav1, Vav2 and Vav3) differ in their expression. Vav1 is expressed only in hematopoietic cells and is involved in the formation of the immune synapse. Vav2 and Vav3 are more ubiquitously expressed. Vav proteins contain the Dbl homology domain, which confers GEF activity, as well as protein interaction domains that allow them to function in pathways regulating actin cytoskeleton organization (reviewed in 1). Phosphorylation stimulates the GEF activity of Vav protein towards Rho/Rac (2,3).
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For Research Use Only. Not For Use In Diagnostic Procedures.
Cell Signaling Technology® is a trademark of Cell Signaling Technology, Inc.
This antibody is developed, validated, and produced by CST using in part technology under license (granting certain rights including those under U.S. Patent No. 5,675,063) from Epitomics, Inc.