Product Pathways - Translational Control
IMP1 Antibody #2852
| Applications | Reactivity | Sensitivity | MW (kDa) | Source |
|---|---|---|---|---|
| W | H | Endogenous | 64 | Rabbit |
Applications Key:
W=Western Blotting
Reactivity Key:
H=Human
Species cross-reactivity is determined by Western blot.
Specificity / Sensitivity
IMP1 Antibody detects endogenous levels of total IMP1 protein.
Source / Purification
Polyclonal antibodies are produced by immunizing rabbits with a synthetic peptide (KLH-coupled) corresponding to the sequence of human IMP1. Antibodies are purified by peptide affinity chromatography.
Western Blotting
Western blot analysis of extracts from various cell types using IMP1 Antibody.
Background
Insulin-like growth factor-II mRNA-binding proteins (IMPs) belong to a family of zipcode-binding proteins (1,2). Three members of this family, IMP1, IMP2 and IMP3, have been identified (1,2). They contain two RNA recognition motifs and four K homology domains and were found to function in the mRNA localization, turnover and translation control (1,2). These proteins have been implicated in a variety of physiological and pathological processes such as growth and development (3), testicular neoplasia (4) and melanocytic neoplasia (5).
- Nielsen, F.C. et al. (2002) J Cell Sci 115, 2087-97.
- Nielsen, J. et al. (2003) Biochem J 376, 383-91.
- Hansen, T.V. et al. (2004) Mol Cell Biol 24, 4448-64.
- Hammer, N.A. et al. (2005) Reproduction 130, 203-12.
- Pryor, J.G. et al. (2008) Mod Pathol, Epub ahead of print.
Application References
Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know!
Companion Products
- 9997 Tris Buffered Saline with Tween 20 (TBST - 10X)
- 9998 BSA
- 9999 Nonfat Dry Milk
- 7071 Phototope®-HRP Western Blot Detection System, Anti-rabbit IgG, HRP-linked Antibody
- 7074 Anti-rabbit IgG, HRP-linked Antibody
- 7720 Prestained Protein Marker, Broad Range (Premixed Format)
- 7727 Biotinylated Protein Ladder Detection Pack
- 7003 20X LumiGLO® Reagent and 20X Peroxide
This product is for in vitro research use only and is not intended for use in humans or animals. This product is not intended for use as therapeutic or in diagnostic procedures.
