Cell Signaling Technology

Product Pathways - Translational Control

IMP1 Antibody #2852

Applications Reactivity Sensitivity MW (kDa) Source
W H Endogenous 64 Rabbit

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.

Protocols

Specificity / Sensitivity

IMP1 Antibody detects endogenous levels of total IMP1 protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the sequence of human IMP1. Antibodies are purified by peptide affinity chromatography.

Western Blotting

Western Blotting

Western blot analysis of extracts from various cell types using IMP1 Antibody.

Background

Insulin-like growth factor-II mRNA-binding proteins (IMPs) belong to a family of zipcode-binding proteins (1,2). Three members of this family, IMP1, IMP2, and IMP3, have been identified (1,2). They contain two RNA recognition motifs, four K homology domains, and were found to function in mRNA localization, turnover, and translation control (1,2). Research studies have implicated these proteins in a variety of physiological and pathological processes, such as growth and development (3), testicular neoplasia (4), and melanocytic neoplasia (5).

  1. Nielsen, F.C. et al. (2002) J Cell Sci 115, 2087-97.
  2. Nielsen, J. et al. (2003) Biochem J 376, 383-91.
  3. Hansen, T.V. et al. (2004) Mol Cell Biol 24, 4448-64.
  4. Hammer, N.A. et al. (2005) Reproduction 130, 203-12.
  5. Pryor, J.G. et al. (2008) Mod Pathol 21, 431-7.

Application References

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Companion Products

For Research Use Only. Not For Use In Diagnostic Procedures.

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