Product Pathways - Cell Cycle / Checkpoint
CDK7 (MO1) Mouse mAb #2916
|2916S||100 µl (20 western blots)||---||In Stock||---|
|2916P||40 µl (8 western blots)||---||In Stock||---|
|2916||carrier free and custom formulation / quantity||email request|
Already purchased this product? Write a Review.
|W||1:2000||Human, Rat||Endogenous||40||Mouse IgG2b|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting, IP=Immunoprecipitation, IHC-P=Immunohistochemistry (Paraffin)
Specificity / Sensitivity
CDK7 (MO1) Mouse mAb detects endogenous levels of total CDK7 protein. The antibody does not cross-react with other CDKs.
Source / Purification
Monoclonal antibody is produced by immunizing animals with recombinant human CDK7.
Western blot analysis of extracts from SK-N-MC and C6 cells, using CDK7 (MO1) Mouse mAb.
CDK-activating kinase (CAK) is a complex of CDK7 and cyclin H. The complex is involved in cell cycle regulation by phosphorylating an activating residue in the T-loop domain of cdks (1). Regulation of CAK activity is mediated by T-loop phosphorylation and by association with MAT1, both of which enhance its kinase activity toward the CTD of RNA polymerase II (2,3) and other substrates such as p53 (4). CAK is an essential component of the transcription complex TFIIH and may interact directly with TFIIH helicases (5).
- Bartkova, J. et al. (1996) Int. J. Cancer 66, 732-737. Applications: Western Blotting, IC-IF.
Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know!
For Research Use Only. Not For Use In Diagnostic Procedures.
Cell Signaling Technology® is a trademark of Cell Signaling Technology, Inc.