Product Pathways - Lymphocyte Signaling
RANTES (P20) Antibody #2988
Reactivity Key: H=Human Mk=Monkey
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
Specificity / Sensitivity
RANTES (P20) Antibody detects endogenous levels of total human RANTES protein.
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro20 of human RANTES. Antibodies were purified by protein A and peptide affinity chromatography.
Western blot analysis of extracts from differentiated THP-1 cells, untreated or treated overnight with LPS, using RANTES (P20) Antibody.
RANTES/CCL5 (regulated upon activation, T cell expressed and secreted) is a member of the "C-C" or β family of chemokines that induce inflammation and are associated with a number of inflammatory disorders (1,2). RANTES is produced and secreted mainly by CD8+ T cells, macrophages, and platelets, as well as epithelial cells, fibroblasts and some solid tumors (2-7). RANTES acts as a chemoattractant and has other regulatory functions on a number of cell types including monocytes, memory T cells, NK cells, eosinophils, basophils, dendritic cells, and mast cells (3, 7-9). Signaling by RANTES is mediated by several G-protein coupled receptors (GPCRs), including CCR1, CCR3, CCR4 and CCR5.
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- Schall, T.J. et al. (1988) J Immunol 141, 1018-25.
- Kameyoshi, Y. et al. (1992) J Exp Med 176, 587-92.
- Rathanaswami, P. et al. (1993) J Biol Chem 268, 5834-9.
- Mattei, S. et al. (1994) Int J Cancer 56, 853-7.
- Stellato, C. et al. (1995) J Immunol 155, 410-8.
- Schall, T.J. et al. (1990) Nature 347, 669-71.
- Kuna, P. et al. (1992) J Immunol 149, 636-42.
- Mattoli, S. et al. (1995) Biochem Biophys Res Commun 209, 316-21.
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For Research Use Only. Not For Use In Diagnostic Procedures.