Product Pathways - Metabolism
IRS-2 (L1326) Antibody #3089
|3089S||100 µl (10 western blots)||---||In Stock||---|
|3089||carrier free and custom formulation / quantity||email request|
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|W||1:1000||Human, Mouse, Rat||Endogenous||185||Rabbit|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting, IP=Immunoprecipitation
Specificity / Sensitivity
IRS-2 (L1326) Antibody detects endogenous levels of total IRS-2 protein. It does not cross-react with IRS-1.
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu1326 of human IRS-2. Antibodies are purified by protein A and peptide affinity chromatography.
Insulin Receptor Substrate 2 (IRS-2) is one of the major substrates of the insulin receptor kinase (1). In vertebrates, IRS-2 functions as a scaffolding protein to coordinate separate branches of the Insulin/IGF-signaling cascades (2). IRS-2 is essential for normal nutrient homeostasis because it mediates both peripheral insulin action and the effect of IGF-1 on B-cell growth. Mice lacking IRS-2 fail to maintain sufficient compensatory insulin secretion and develop diabetes as young adults (3).
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For Research Use Only. Not For Use In Diagnostic Procedures.
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