Product Pathways - Glucose Metabolism
GPX1 (C8C4) Rabbit mAb #3286
PhosphoSitePlus® protein, site, and accession data: GPX1
| Applications | Reactivity | Sensitivity | MW (kDa) | Isotype |
|---|---|---|---|---|
| W | H | Endogenous | 22 | Rabbit IgG |
Applications Key:
W=Western Blotting
Reactivity Key:
H=Human
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
Protocols
- 3286:
- Western Blotting
Specificity / Sensitivity
GPX1 (C8C4) Rabbit mAb detects endogenous levels of total GPX1 protein.
Source / Purification
GPX1 (C8C4) Rabbit mAb is produced by immunizing rabbits with a synthetic peptide corresponding to the sequence of human GPX1.
Western Blotting
Western blot analysis of extracts from 293 and THP-1 cells using GPX1 (C8C4) Rabbit mAb.
Background
Glutathione peroxidase 1 (GPX1) is a cytosolic selenoprotein which reduces hydrogen peroxide to water (1). GPX1 is the most abundant and ubiquitous among the five GPX isoforms identified so far (2). It is an important component in the anti-oxidative defense in cells and is associated with a variety of disease conditions, such as colon cancer (3), coronary artery disease (4) and insulin resistance (1).
- McClung, J.P. et al. (2004) Proc. Natl. Acad. Sci. USA 101, 8852-8857.
- Hamanishi, T. et al. (2004) Diabetes 53, 2455-2460.
- Drew, J.E. et al. (2005) FEBS Lett. 579, 6135-6139.
- Winter, J.P. et al. (2003) Coron. Artery Dis. 14, 149-153.
Application References
- Hawkes, W.C. et al. (2012) J Cell Biochem 113, 61-9. Applications: Western Blotting
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This product is intended for research purposes only. The product is not intended to be used for therapeutic or diagnostic purposes in humans or animals.
