Product Pathways - TGF-beta/Smad Signaling
Endoglin Antibody (Mouse Specific) #3290
|3290S||100 µl (10 western blots)||---||In Stock||---|
|3290||carrier free and custom formulation / quantity||email request|
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|W||1:1000||Mouse||Transfected Only||79, 81||Rabbit|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting
Specificity / Sensitivity
Endoglin Antibody (Mouse Specific) detects transfected levels of mouse endoglin protein.
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro430 of mouse endoglin. Antibodies are purified by peptide affinity chromatography.
Endoglin (ENG, CD105) is an auxiliary receptor for the TGF-β receptor complex, functioning in related signaling pathways (1,2). Endoglin is a transmembrane protein that exists as a disulfide-linked homodimer. It is mainly expressed in vascular and connective tissues and in endothelial and stromal cells. Upregulated endoglin expression has been reported during wound healing and tumor vascularization, and in inflammatory tissues and developing embryos (1-4). Mutations in endoglin have been found to be a causal factor of hereditary hemorrhagic telangiectasia (HHT), a disease characterized by malformation of vascular structure (5,6). The importance of this protein for normal and tumor vascular function makes it a good marker for endothelial cell proliferation as well as a potential therapeutic target in cancer (4-6).
- Bernabeu, C. et al. (2007) J Cell Biochem 102, 1375-88.
- Zhu, Y. et al. (2003) Stroke 34, 2483-8.
- Quintanilla, M. et al. (2003) Oncogene 22, 5976-85.
- Dallas, N.A. et al. (2008) Clin Cancer Res 14, 1931-7.
- ten Dijke, P. et al. (2008) Angiogenesis 11, 79-89.
- Fernández-L, A. et al. (2006) Clin Med Res 4, 66-78.
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For Research Use Only. Not For Use In Diagnostic Procedures.
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