Cell Signaling Technology

Product Pathways - Ca / cAMP / Lipid Signaling

ApoA5 (2G1H11) Mouse mAb #3335

Applications Reactivity Sensitivity MW (kDa) Isotype
W IP H Endogenous 41 Mouse IgG1

Applications Key:  W=Western Blotting  IP=Immunoprecipitation
Reactivity Key:  H=Human
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.

Protocols

Specificity / Sensitivity

ApoA5 (2G1H11) Mouse mAb recognizes endogenous levels of total ApoA5 protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a purified recombinant fragment of ApoA5 protein expressed in E. Coli.

Western Blotting

Western Blotting

Western blot analysis of Hep G2 cell extracts and human plasma using ApoA5 (2G1H11) Mouse mAb.

Background

Apolipoproteins are plasma lipoproteins that function as transporters of lipids and cholesterol in the circulatory system. Chylomicrons are a fundamental class of apolipoproteins containing very low-density lipoproteins (VLDL), intermediate-density lipoproteins (IDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) (1,2).

Apolipoprotein A5 (ApoA5) is an HDL that plays a role in the maintenance of lipid homeostasis by promoting plasma triglyceride hydrolysis (3,4). Research evidence suggests that ApoA5 may play a role in the early phases of hepatic regeneration (4).

  1. Kwiterovich, P.O. (2000) Am J Cardiol 86, 5L-10L.
  2. Hussain, M.M. (2000) Atherosclerosis 148, 1-15.
  3. Beckstead, J.A. et al. (2003) Biochemistry 42, 9416-23.
  4. van der Vliet, H.N. et al. (2001) J Biol Chem 276, 44512-20.

Application References

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Companion Products

For Research Use Only. Not For Use In Diagnostic Procedures.

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