Product Pathways - Jak/Stat Pathway
Cytokine Receptor Common beta-Chain Antibody #3432
|W||H M R Mk Mi||Endogenous||100||Rabbit|
Reactivity Key: H=Human M=Mouse R=Rat Mk=Monkey Mi=Mink
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
Specificity / Sensitivity
Cytokine Receptor Common beta-Chain Antibody detects endogenous levels of total cytokine receptor common beta-chain protein independent of phosphorylation.
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the carboxy terminus of human cytokine receptor common beta-chain. Antibodies are purified by protein A and peptide affinity chromatography.
The common beta-chain (beta-c) of the granulocyte macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3) and IL-5 receptors is the major signaling subunit of these receptors, coupling ligand binding to multiple biological activities (1-3). Tyrosine phosphorylation of cytokine receptor common beta-chain is one of the first events in GM-CSF, IL-3 and IL-5 receptor activation and in signaling initiation (4). Serine phosphorylation within the 14-3-3 binding sequence of the common beta-chain is also involved in GM-CSF, IL-3 and IL-5 receptor-specific functions (5,6).
- Kitamura, T. et al. (1991) Cell 66, 1165-1174.
- Tavernier, J. et al. (1991) Cell 66, 1175-1184.
- Hayashida, K. et al. (1990) Proc. Natl. Acad. Sci. USA 87, 9655-9659.
- Muto, A. et al. (1996) J. Exp. Med. 183, 1911-1926.
- Stomski, F.C. et al. (1999) Blood 94, 1933-1942.
- Guthridge, M.A. et al. (2000) Mol. Cell 6, 99-108.
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For Research Use Only. Not For Use In Diagnostic Procedures.