Product Pathways - Tyrosine Kinase / Adaptors
FGF Receptor 1 Antibody #3472
|3472S||100 µl (10 western blots)||---||In Stock||---|
|3472||carrier free and custom formulation / quantity||email request|
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|W||1:1000||Human||Transfected Only||120, 145||Rabbit|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting, IP=Immunoprecipitation
Species predicted to react based on 100% sequence homology: Mouse, Rat.
Specificity / Sensitivity
FGF Receptor 1 Antibody detects transfected levels of FGF receptor 1. It does not cross-react with other FGF receptor family members.
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the amino-terminal residues of human FGF receptor 1. Antibodies are purified by protein A and peptide affinity chrmatography.
Fibroblast growth factors (FGFs) produce mitogenic and angiogenic effects in target cells by signaling through cell surface receptor tyrosine kinases. There are four members of the FGF receptor family: FGFR1 (flg), FGFR2 (bek, KGFR), FGFR3, and FGFR4. Each receptor contains an extracellular ligand binding domain, a transmembrane domain, and a cytoplasmic kinase domain (1). Following ligand binding and dimerization, the receptors are phosphorylated at specific tyrosine residues (2). Seven tyrosine residues in the cytoplasmic tail of FGFR1 can be phosphorylated: Tyr463, 583, 585, 653, 654, 730, and 766. Tyr653 and Tyr654 are important for catalytic activity of activated FGFR and are essential for signaling (3). The other phosphorylated tyrosine residues may provide docking sites for downstream signaling components such as Crk and PLCγ (4,5).
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For Research Use Only. Not For Use In Diagnostic Procedures.
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