Product Pathways - Neuroscience
Caspr2 Antibody #3731
|3731S||100 µl (10 western blots)||---||In Stock||---|
|3731||carrier free and custom formulation / quantity||email request|
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|W||1:1000||Human, Mouse, Rat||Endogenous||150||Rabbit|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting
Specificity / Sensitivity
Caspr2 Antibody detects endogenous levels of total Caspr2 protein.
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide sourrounding Glu1320 of human Caspr2. Antibodies are purified by protein A and peptide affinity chromatography.
Contactin-associated protein 2 (Caspr2) is a type I transmembrane protein and member of the neurexin superfamily that mediates nervous system cell-cell interactions through the Neurexin IV-Caspr-Paranodin (NCP) complex (1). A multiprotein complex consisting of TAG-1, Caspr2, K+ channel, PSD95 and protein 4.1B mediates the molecular interactions at the juxtaparanodal region of myelinated axons, with homophilic TAG-1 interactions mediating the binding of this complex to glia (2,3).
Caspr2 protein localizes to juxtaparanodal regions of myelinated axons where it forms a cis-complex with the immunoglobulin-like cell adhesion molecule TAG-1. Caspr2 also binds to Shaker K+ channels Kv1.1, Kv1.2, and their Kvβ2 subunit. A PDZ domain at the Caspr2 carboxy terminus mediates the Caspr2-K+ channel association. Caspr2 is required for proper K+ channel localization, as Caspr2 deletion causes the redistribution of channels along the internodes (1-3). Furthermore, Caspr2 binds to protein 4.1B and connects the protein complex to the axonal cytoskeleton (4). Mutations in the Caspr2 gene have been linked to focal epilepsy, cortical dysplasia and Gilles de la Tourette syndrome (5,6).
- Poliak, S. et al. (1999) Neuron 24, 1037-47.
- Poliak, S. et al. (2003) J Cell Biol 162, 1149-60.
- Traka, M. et al. (2003) J Cell Biol 162, 1161-72.
- Denisenko-Nehrbass, N. et al. (2003) Eur J Neurosci 17, 411-6.
- Verkerk, A.J. et al. (2003) Genomics 82, 1-9.
- Strauss, K.A. et al. (2006) N Engl J Med 354, 1370-7.
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