Product Pathways - Adhesion
Integrin α6 Antibody #3750
|3750S||100 µl (10 western blots)||---||In Stock||---|
|3750||carrier free and custom formulation / quantity||email request|
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|W||1:1000||Human, Mouse, Rat, Monkey||Endogenous||150, 125||Rabbit|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting
Specificity / Sensitivity
Integrin α6 Antibody detects endogenous levels of total integrin α6 protein.
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding residues surrounding Gly571 of human integrin α6. Antibodies are purified by peptide affinity chromatography.
Integrins are α/β heterodimeric cell surface receptors that play a pivotal role in cell adhesion and migration, as well as in growth and survival (1,2). The integrin family contains at least 18 α and 8 β subunits that form 24 known integrins with distinct tissue distribution and overlapping ligand specificities (3). Integrins not only transmit signals to cells in response to the extracellular environment (outside-in signaling), but also sense intracellular cues to alter their interaction with the extracellular environment (inside-out signaling) (1,2).
Integrin α6 is a 120 kDa protein with two splice variants, integrin α6, 6A and 6B (3), which function as receptors for laminins on the basal membrane to mediate cellular adhesion events (4-6). α6 integrins have been shown to play an important role in hematopoietic stem and progenitor cell homing to the bone marrow.
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- Sonnenberg, A. et al. (1990) J Cell Biol 110, 2145-55.
- Sonnenberg, A. et al. (1993) J Cell Sci 106 ( Pt 4), 1083-102.
- Shaw, L.M. et al. (1990) J Cell Biol 110, 2167-74.
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