Product Pathways - Neuroscience
α-Synuclein (D37A6) XP® Rabbit mAb (Alexa Fluor® 555 Conjugate) #3809
|3809S||100 µl (50 tests)||---||In Stock||---|
|3809||carrier free and custom formulation / quantity||email request|
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|IF-F||1:50||Mouse, Rat||Endogenous||Rabbit IgG|
Species cross-reactivity is determined by western blot using the unconjugated antibody.
Applications Key: IF-F=Immunofluorescence (Frozen)
Specificity / Sensitivity
α-Synuclein (D37A6) XP® Rabbit mAb (Alexa Fluor® 555 Conjugate) detects endogenous levels of the α isoform of synuclein protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Glu105 of mouse α-synuclein protein.
Confocal immunofluorescent analysis of normal rat hippocampus using α-Synuclein (D37A6) XP® Rabbit mAb (Alexa Fluor® 555 Conjugate) (red) and GFAP (GA5) Mouse mAb (Alexa Fluor® 488 Conjugate) #3655 (green). Blue pseudocolor = DRAQ5® #4084 (fluorescent DNA dye). Gated area shown at 20X magnification on right.
This Cell Signaling Technology antibody is conjugated to Alexa Fluor® 555 fluorescent dye and tested in-house for direct immunofluorescent analysis in rat brain. The antibody is expected to exhibit the same species cross-reactivity as the unconjugated α-Synuclein (D37A6) XP® Rabbit mAb #4179.
α-Synuclein is a protein of 140-amino acids expressed abundantly in the brain. α-Synuclein is also the main component of pathogenic Lewy bodies and Lewy neurites. Research studies have shown that mutations of the α-synuclein gene are linked to Parkinson's disease (1).
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For Research Use Only. Not For Use In Diagnostic Procedures.
XP® is a trademark of Cell Signaling Technology, Inc.
DRAQ5® is a registered trademark of Biostatus Limited.
Cell Signaling Technology® is a trademark of Cell Signaling Technology, Inc.
The Alexa Fluor® dye antibody conjugates in this product are sold under license from Molecular Probes, Inc., for research use only, except for use in combination with DNA microarrays. The Alexa Fluor® dyes (except for Alexa Fluor® 430 dye) are covered by pending and issued patents. Alexa Fluor® is a registered trademark of Molecular Probes, Inc.