Product Pathways - Neuroscience
α-Synuclein (D37A6) XP® Rabbit mAb (Alexa Fluor® 555 Conjugate) #3809
PhosphoSitePlus® protein, site, and accession data: SNCA
| Applications | Reactivity | Sensitivity | Isotype |
|---|---|---|---|
| IF-F | M R | Endogenous | Rabbit IgG |
Applications Key:
IF-F=Immunofluorescence (Frozen)
Reactivity Key:
M=Mouse
R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
Protocols
- 3809:
- Immunofluorescence
Specificity / Sensitivity
α-Synuclein (D37A6) XP® Rabbit mAb (Alexa Fluor® 555 Conjugate) detects endogenous levels of the α isoform of synuclein protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Glu105 of mouse α-synuclein protein.
IF-F
Confocal immunofluorescent analysis of normal rat hippocampus using α-Synuclein (D37A6) XP® Rabbit mAb (Alexa Fluor® 555 Conjugate) (red) and GFAP (GA5) Mouse mAb (Alexa Fluor® 488 Conjugate) #3655 (green). Blue pseudocolor = DRAQ5® #4084 (fluorescent DNA dye). Gated area shown at 20X magnification on right.
Description
This Cell Signaling Technology antibody is conjugated to Alexa Fluor® 555 fluorescent dye and tested in-house for direct immunofluorescent analysis in rat brain. The antibody is expected to exhibit the same species cross-reactivity as the unconjugated α-Synuclein (D37A6) XP® Rabbit mAb #4179.
Background
α-Synuclein is a protein of 140-amino acids expressed abundantly in the brain. α-Synuclein is also the main component of pathogenic Lewy bodies and Lewy neurites. Research studies have shown that mutations of the α-synuclein gene are linked to Parkinson's disease (1).
Application References
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For Research Use Only. Not For Use In Diagnostic Procedures.
