Product Pathways - Lymphocyte Signaling
LSP1 Antibody #3812
|3812S||100 µl (10 western blots)||---||In Stock||---|
|3812||carrier free and custom formulation / quantity||email request|
Already purchased this product? Write a Review.
|W||1:1000||Human, Mouse, Rat||Endogenous||52||Rabbit|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting
Specificity / Sensitivity
LSP1 Antibody detects endogenous levels of LSP1 protein independent of phosphorylation.
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding amino acid 37-48 of human LSP1. Antibodies are purified by protein A and peptide affinity chromatography.
LSP1 is a 52 kDa leukocyte-specific protein expressed in B cells, T cells, macrophages and neutrophils (1). The protein binds F-actin through its C-terminal actin-binding repeat and regulates cytoskeletal-related cellular movement such as polarization, chemotaxis and locomotion (2-4). LSP1 is a phospho-protein and has been identified as a major substrate of MAP kinase and PKC in lymphocytes and neutrophils (5-7). The phosphorylation is possibly related to its cytoskeletal regulatory function.
- Li, Y. et al. (1995) J. Immunol. 155, 3563-3569.
- Zhang, Q. et al. (2000) J. Immunol. 165, 2052-2058.
- Li, Y. et al. (2000) Blood 96, 1100-1105.
- Wang, C. et al. (2002) J. Immunol. 169, 415-423.
- Huang, C. K. et al. (1997) J. Biol. Chem. 272, 17-19.
- Matsumoto, N. et al. (1995) J. Biochem. (Tokyo) 117, 222-229.
- Carballo, E. et al. (1996) J. Immunol. 156, 1709-1713.
Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know!
For Research Use Only. Not For Use In Diagnostic Procedures.
Cell Signaling Technology® is a trademark of Cell Signaling Technology, Inc.