Product Pathways - Translational Control
hnRNP A0 Antibody #4046
|W IP IF-IC||H M R Mk||Endogenous||32, 34||Rabbit|
Reactivity Key: H=Human M=Mouse R=Rat Mk=Monkey
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
Specificity / Sensitivity
hnRNP A0 Antibody detects endogenous levels of total hnRNP A0 protein. This antibody cross-reacts with hnRNP A2/B1 protein.
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the sequence of human hnRNP A0. Antibodies are purified by protein A and peptide affinity chromatography.
Western blot analysis of extracts from HeLa and NIH/3T3 cells using hnRNP A0 Antibody.
Heterogeneous nuclear ribonucleoprotein A0 (hnRNP A0) is a member of the hnRNP A/B family of related RNA binding proteins that bind pre-mRNA and are involved in the processing, metabolism, and transport of nuclear pre-mRNA transcripts (1). The A/B subfamily of hnRNP includes A1, A2/B1, A3, and A0. hnRNP A0 is phosphorylated at Ser84 by MAPKAPK-2 in response to LPS treatment in mouse macrophage cells, which might play a key role in stimulating translation of the TNF-α message (2).
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For Research Use Only. Not For Use In Diagnostic Procedures.