Product Pathways - Metabolism
ACSL1 Antibody #4047
|W IHC-P||H M R||Endogenous||78||Rabbit|
Reactivity Key: H=Human M=Mouse R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
Specificity / Sensitivity
ACSL1 Antibody detects endogenous levels of total ACSL1 protein.
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to a sequence of human ACSL1. Antibodies are purified by peptide affinity chromatography.
Immunohistochemical analysis of paraffin-embedded human breast carcinoma using ACSL1 Antibody.
Immunohistochemical analysis of paraffin-embedded human lung carcinoma using ACSL1 Antibody.
Mammalian long-chain acyl-CoA synthetase (ACSL) catalyzes the ligation of the fatty acid to CoA to form fatty acyl-CoA in a two-step reaction (1). Five isoforms of ACSL have been identified (1). These isoforms have different substrate preferences and subcellular localizations (1). Overexpression of ACSL1 results in changes to fatty acid metabolism in rat primary hepatocytes (2).
- Mashek, D.G. et al. (2004) J Lipid Res 45, 1958-61.
- Li, L.O. et al. (2006) J Biol Chem 281, 37246-55.
- Li, L.O. et al. (2009) J Biol Chem , .
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For Research Use Only. Not For Use In Diagnostic Procedures.