Product Pathways - Translational Control
THEX1 (D66A11) Rabbit mAb #4055
|W IP||H||Endogenous||46||Rabbit IgG|
Reactivity Key: H=Human
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
Specificity / Sensitivity
THEX1 (D66A11) Rabbit mAb detects endogenous levels of total THEX1 protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to the sequence around Pro33 of human THEX1.
THEX1 (3’hExo) is a 3’ exonuclease that may play a role in the degradation of histone mRNA transcripts (1). A recently identified member of the DEDDh 3' exonuclease family, THEX1 binds the conserved stem-loop structure found at the 3’ end of mRNA in vitro (2). The binding of THEX1 to mRNA requires the presence of a terminal ACCCA sequence and is enhanced by the concurrent binding of stem-loop binding protein (SLBP). Cleavage of histone mRNA by THEX1 exonuclease may help produce the rapid turnover of histone mRNA transcripts associated with the completion of DNA replication (3). Additional evidence suggests that THEX1 may be responsible for excising the remaining few 3’ nucleotides following cleavage by a different enzyme (4).
- Dominski, Z. and Marzluff, W.F. (1999) Gene 239, 1-14.
- Dominski, Z. et al. (2003) Mol Cell 12, 295-305.
- Yang, X.C. et al. (2006) J Biol Chem 281, 30447-54.
- Mullen, T.E. and Marzluff, W.F. (2008) Genes Dev 22, 50-65.
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For Research Use Only. Not For Use In Diagnostic Procedures.