Product Pathways - Metabolism
SNARK/NUAK2 Antibody #4100
|W||M (H) (R)||Endogenous||70||Rabbit|
Reactivity Key: H=Human M=Mouse R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
Specificity / Sensitivity
SNARK/NUAK2 Antibody detects endogenous levels of total SNARK/NUAK2 protein.
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the sequence of human SNARK/NUAK2. Antibodies are purified by protein A and peptide affinity chromatography.
SNARK was identified as an SNF1/AMPK-related kinase and member of the AMPK catalytic subunit family (1,2). This enzyme was separately identified as a TNFα-induced SNF1-like kinase 2 (NUAK2) (3). The kinase activity of SNARK/NUAK2 is increased by AMP and AICAR (1). SNARK/NUAK2 activity is regulated by a variety of cellular stresses such as endoplasmic reticulum (ER) stress and oxidative stresses (4), suggesting that SNARK/NUAK2 is a signaling molecule involved in the cell stress response (4).
- Lefebvre, D.L. et al. (2001) Biochem J 355, 297-305.
- Suzuki, A. et al. (2003) Biochem Biophys Res Commun 311, 156-61.
- Yamamoto, H. et al. (2008) Biochem Biophys Res Commun 365, 541-7.
- Lefebvre, D.L. and Rosen, C.F. (2005) Biochim Biophys Acta 1724, 71-85.
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For Research Use Only. Not For Use In Diagnostic Procedures.