Product Pathways - Tyrosine Kinase / Adaptors
PZR Antibody #4157
|4157S||100 µl (10 western blots)||---||In Stock||---|
|4157||carrier free and custom formulation / quantity||email request|
Already purchased this product? Write a Review.
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting, IP=Immunoprecipitation
Specificity / Sensitivity
PZR Antibody detects endogenous levels of total PZR protein.
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the N terminus of human PZR. Antibodies are purified by protein A and peptide affinity chromatography.
PZR (Protein zero related) is an immunoglobulin superfamily protein that specifically binds the tyrosine phosphatase SHP-2 through its intracellular immunoreceptor tyrosine-based inhibitory motifs (ITIMs) (1,2). PZR is phosphorylated by c-Src, c-Fyn, c-Lyn, Csk, and c-Abl (3). PP1, a Src family kinase inhibitor, inhibits PZR phosphorylation (4,5). There are three alternatively spliced isoforms, designated as PZR, PZRa, and PZRb; both PZRa and PZRb lack ITIMs (6,7). PZR is the main receptor of ConA and has an important role in cell signaling via c-Src (4). PZR is expressed in many cell types and is localized to cell contacts and intracellular granules in BAECs and mesothelioma (REN) cells. PZR has been implicated as a cell adhesion protein that may be involved in SHP-2-dependent signaling at interendothelial cell contacts (3). Hypertyrosine phosphorylation of PZR was observed during embryogenesis in a mouse model of Noonan syndrome (8).
- Zhao, Z.J. and Zhao, R. (1998) J Biol Chem 273, 29367-72.
- Zhao, R. and Zhao, Z.J. (2000) J Biol Chem 275, 5453-9.
- Kusano, K. et al. Endothelium 15, 127-36.
- Zhao, R. et al. (2002) J Biol Chem 277, 7882-8.
- Zhao, R. et al. (2003) J Biol Chem 278, 42893-8.
- Zannettino, A.C. et al. (2003) Biochem J 370, 537-49.
- Zhao, R. and Zhao, Z.J. (2003) Biochem Biophys Res Commun 303, 1028-33.
- Eminaga, S. and Bennett, A.M. (2008) J Biol Chem 283, 15328-38.
Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know!
For Research Use Only. Not For Use In Diagnostic Procedures.
Cell Signaling Technology® is a trademark of Cell Signaling Technology, Inc.