Product Pathways - Chromatin Regulation / Epigenetics
TFIIB (2F6A3H4) Mouse mAb #4169
|4169S||100 µl (10 western blots)||---||In Stock||---|
|4169||carrier free and custom formulation / quantity||email request|
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|W||1:1000||Human, Mouse, Rat, Monkey||Endogenous||32||Mouse IgG2b|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting, IP=Immunoprecipitation
Specificity / Sensitivity
TFIIB (2F6A3H4) Mouse mAb detects endogenous levels of total TFIIB protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with recombinant human TFIIB protein.
TFIIB (also known as GTF2B, TF2B and general transcription factor IIB) is a ubiquitously expressed transcription factor that plays a central role in the assembly of the transcription pre-initiation complex through direct recruitment of RNA polymerase II (1,2). TFIIB functions as a bridge between promoter-bound TFIID and RNA polymerase II. In addition to interacting with promoter-bound TFIID and TFIIA, TFIIB makes extensive contacts with the core promoter via two independent DNA-binding modules. TFIIB may also be a target of transcriptional activator proteins that act to stimulate pre-initiation complex assembly.
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For Research Use Only. Not For Use In Diagnostic Procedures.
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