Cell Signaling Technology

Product Pathways - Metabolism

GATA-2 Antibody #4595

Applications Reactivity Sensitivity MW (kDa) Source
W H M R Endogenous 51 Rabbit

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human  M=Mouse  R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.

Protocols

Specificity / Sensitivity

GATA-2 Antibody detects endogenous levels of total GATA-2 protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the sequence of human GATA-2. Antibodies are purified by protein A and peptide affinity chromatography.

Western Blotting

Western Blotting

Western blot analysis of extracts from HeLa and 293 cells, using GATA-2 Antibody.

Background

The zinc finger transcription factor GATA-2 is widely expressed and plays an essential role in many developmental processes (1). Studies on GATA-2 knockout mice indicate that this protein is required in hematopoiesis (2). GATA-2 also inhibits the differentiation of white (3) and brown adipocytes (4) and has been shown to suppress the proliferation of neuronal progenitor cells (5).

  1. Tong, Q. et al. (2003) Drug News Perspect. 16, 585-588.
  2. Tsai, F.Y. et al. (1994) Nature 371, 221-226.
  3. Tong, Q. et al. (2005) Mol. Cell. Biol. 25, 706-715.
  4. Tsai, J. et al. (2005) EMBO Rep. 6, 879-884.
  5. El Wakil, A. et al. (2006) Development 133, 2155-2165.

Application References

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Companion Products

For Research Use Only. Not For Use In Diagnostic Procedures.

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