Product Pathways - Neuroscience
α-Synuclein (D37A6) XP® Rabbit mAb (Alexa Fluor® 647 Conjugate) #4639
|IF-F||M R||Endogenous||Rabbit IgG|
Reactivity Key: M=Mouse R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
Specificity / Sensitivity
α-Synuclein (D37A6) XP® Rabbit mAb (Alexa Fluor® 647 Conjugate) detects endogenous levels of the α isoform of synuclein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide surrounding Glu105 of mouse α-synuclein protein.
Confocal immunofluorescent analysis of normal rat hippocampus using α-Synuclein (D37A6) XP® Rabbit mAb (Alexa Fluor® 647 Conjugate) (blue pseudocolor) and GFAP (GA5) Mouse mAb (Alexa Fluor® 488 Conjugate) #3655 (green). Red = Propidium Iodide (PI)/RNase Staining Solution #4087 (fluorescent DNA dye).
This Cell Signaling Technology antibody is conjugated to Alexa Fluor® 647 fluorescent dye and tested in-house for direct immunofluorescent analysis in rat brain. The antibody is expected to exhibit the same species cross-reactivity as the unconjugated α-Synuclein (D37A6) XP® Rabbit mAb #4179.
α-Synuclein is a protein of 140-amino acids expressed abundantly in the brain. α-Synuclein is also the main component of pathogenic Lewy bodies and Lewy neurites. Research studies have shown that mutations of the α-synuclein gene are linked to Parkinson's disease (1).
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For Research Use Only. Not For Use In Diagnostic Procedures.