Product Pathways - Cytoskeletal Signaling
Vav1 (D45G3) Rabbit mAb #4657
|4657S||100 µl (10 western blots)||---||In Stock||---|
|4657P||40 µl (4 western blots)||---||In Stock||---|
|4657||carrier free and custom formulation / quantity||email request|
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Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting, IP=Immunoprecipitation
Species predicted to react based on 100% sequence homology: Monkey.
Specificity / Sensitivity
Vav1 (D45G3) Rabbit mAb recognizes endogenous levels of total Vav1 protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues in the carboxy terminus of human Vav1 protein.
Western blot analysis of extracts from Jurkat, Raji and K-562 cells using Vav1 (D45G3) Rabbit mAb.
Vav proteins belong to the Dbl family of guanine nucleotide exchange factors (GEFs) for Rho/Rac small GTPases. The three identified mammalian Vav proteins (Vav1, Vav2 and Vav3) differ in their expression. Vav1 is expressed only in hematopoietic cells and is involved in the formation of the immune synapse. Vav2 and Vav3 are more ubiquitously expressed. Vav proteins contain the Dbl homology domain, which confers GEF activity, as well as protein interaction domains that allow them to function in pathways regulating actin cytoskeleton organization (reviewed in 1). Phosphorylation stimulates the GEF activity of Vav protein towards Rho/Rac (2,3).
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For Research Use Only. Not For Use In Diagnostic Procedures.
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