Product Pathways - Metabolism
NPC1L1 Antibody #5058
|5058S||100 µl (10 western blots)||---||In Stock||---|
|5058||carrier free and custom formulation / quantity||email request|
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Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting, IP=Immunoprecipitation
Specificity / Sensitivity
NPC1L1 Antibody detects endogenous levels of total NPC1L1 protein.
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to central residues of human NPC1L1 protein. Antibodies were purified by protein A and peptide affinity chromatography.
Niemann-Pick C1-like 1 (NPC1L1) is a transmembrane protein that plays a critical role in cholesterol absorption (1). It is highly expressed in small intestine and localized along the brush border in both human and mouse epithelial cells (2,3). NPC1L1 mediates cholesterol uptake via vesicular endocytosis (4). Ezetimibe, a potent cholesterol absorption inhibitor used to treat hypercholesterolemia (5), inhibits cholesterol uptake by preventing NPC1L1 from incorporating into clathrin-coated vesicles (4).
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For Research Use Only. Not For Use In Diagnostic Procedures.
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