Product Pathways - Cell Cycle / Checkpoint
EAPP (1E4) Mouse mAb #5166
|5166S||100 µl (10 western blots)||---||In Stock||---|
|5166||carrier free and custom formulation / quantity||email request|
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|W||1:1000||Human, Mouse, Rat, Monkey||Endogenous||45||Mouse IgG1|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting, IF-IC=Immunofluorescence (Immunocytochemistry)
Specificity / Sensitivity
EAPP (1E4) Mouse mAb detects endogenous levels of total EAPP protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a recombinant amino-terminal fragment of human EAPP protein.
Western blot analysis of extracts from various cell types using EAPP (1E4) Mouse mAb.
Regulation of the E2F family of transcription factors, primarily through the retinoblastoma protein (pRb), is vital for control of cell proliferation and cell death (reviewed in 1). E2F-associated phosphoprotein (EAPP) was identified as an E2F-family binding protein that modulates E2F-regulated transcription and may be required for S phase entry. EAPP is expressed at varied levels in all tissues and cell types examined and its expression is reduced in nocodazole-arrested cells (2). Mass spectrometry studies have identified multiple EAPP phosphorylation sites including Ser109 and Ser111, but biological consequences of EAPP phosphorylation have yet to be elucidated (3-5).
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