Product Pathways - Cytoskeletal Signaling
Cofilin (D3F9) XP® Rabbit mAb #5175
|5175S||100 µl (10 western blots)||---||In Stock||---|
|5175P||40 µl (4 western blots)||---||In Stock||---|
|5175||carrier free and custom formulation / quantity||email request|
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|W||1:1000||Human, Mouse, Rat, Monkey, Dog||Endogenous||19||Rabbit IgG|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting, IF-IC=Immunofluorescence (Immunocytochemistry)
Specificity / Sensitivity
Cofilin (D3F9) XP® Rabbit mAb detects endogenous levels of total cofilin1 protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to central residues of human cofilin1 protein.
Western blot analysis of extracts from various cell types using Cofilin (D3F9) XP® Rabbit mAb.
Cofilin and actin-depolymerization factor (ADF) are members of a family of essential conserved small actin-binding proteins that play pivotal roles in cytokinesis, endocytosis, embryonic development, stress response, and tissue regeneration (1). In response to stimuli, cofilin promotes the regeneration of actin filaments by severing preexisting filaments (2). The severing activity of cofilin is inhibited by LIMK or TESK phosphorylation at Ser3 of cofilin (3-5). Phosphorylation at Ser3 also regulates cofilin translocation from the nucleus to the cytoplasm (6).
- Eke, I. et al. (2012) J Clin Invest 122, 1529-40. Applications: Western Blotting.
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For Research Use Only. Not For Use In Diagnostic Procedures.
XP® is a trademark of Cell Signaling Technology, Inc.
Cell Signaling Technology® is a trademark of Cell Signaling Technology, Inc.