Product Pathways - Protein Stability
Renin Antibody #5250
|5250S||100 µl (10 western blots)||---||In Stock||---|
|5250||carrier free and custom formulation / quantity||email request|
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Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting
Specificity / Sensitivity
Renin Antibody detects transfected levels of human Renin protein.
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu308 of human renin. Antibodies are purified by protein A and peptide affinity chromatography.
Renin is a secreted proteinase whose enzymatic activity is to convert angiotensinogen into angiotensin I in the plasma, initiating a process that results in an elevation of blood pressure and increased sodium retention by the kidney (1). Renin is synthezed in kidney as a procursor, prorenin, which is released into circulation. Both renin and prorenin can bind to (pro)renin receptor and induce angiotensin-independent signaling events leading to activation of MAPKs and up-regulation of TGF-β1 and matrix proteins (2, 3). Defects in renin can cause renal tubular dysgenesis, a severe autosomal recessive disorder of renal tubular development (4, 5).
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For Research Use Only. Not For Use In Diagnostic Procedures.
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