Product Pathways - Phosphatases
PTP1B Antibody #5311
|5311S||100 µl (10 western blots)||---||In Stock||---|
|5311||carrier free and custom formulation / quantity||email request|
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Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting
Specificity / Sensitivity
PTP1B Antibody detects endogenous levels of total PTP1B protein.
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human PTP1B protein. Antibodies are purified by protein A and peptide affinity chromatography.
Protein-tyrosine phosphatase 1B (PTP1B) is the original member of the protein tyrosine phosphatase (PTP) family of proteins (1). PTP1B is highly expressed in insulin-responsive tissues and negatively regulates insulin, as well as integrin, through dephosphorylation of phosphotyrosine residues (2-4). PTP1B knockout mice show resistance to dietary weight gain and enhanced insulin sensitivity, suggesting a possible role in treatment of obesity as well as type 2 diabetes (5).
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For Research Use Only. Not For Use In Diagnostic Procedures.
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