Cell Signaling Technology

Product Pathways - Metabolism

FABP1 Antibody #5352

Applications Reactivity Sensitivity MW (kDa) Source
W H M R Endogenous 14 Rabbit

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human  M=Mouse  R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.

Protocols

Specificity / Sensitivity

FABP1 Antibody recognizes endogenous levels of total FABP1 protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val101 of human FABP1 protein. Antibodies are purified by protein A and peptide affinity chromatography.

Western Blotting

Western Blotting

Western blot analysis of extracts from Hep G2 cells and human and mouse liver using FABP1 Antibody.

Background

Fatty acid binding proteins (FABPs) bind to fatty acids and other lipids to function as cytoplasmic lipid chaperones (1,2). They participate in the transport of fatty acids and other lipids to various cellular pathways (2). Research studies have shown that common variants of the liver fatty acid binding protein gene, FABP1, play a role in the development of type 2 diabetes and insulin resistance (3).

  1. Tuncman, G. et al. (2006) Proc Natl Acad Sci U S A 103, 6970-5.
  2. Haunerland, N.H. and Spener, F. (2004) Prog Lipid Res 43, 328-49.
  3. Mansego, M.L. et al. (2012) PLoS One 7, e31853.

Application References

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Companion Products

For Research Use Only. Not For Use In Diagnostic Procedures.

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