Product Pathways - Protein Translation
KHSRP Antibody #5398
|5398S||100 µl (10 western blots)||---||In Stock||---|
|5398||carrier free and custom formulation / quantity||email request|
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|W||1:1000||Human, Mouse, Rat, Monkey||Endogenous||82||Rabbit|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting
Specificity / Sensitivity
KHSRP Antibody detects endogenous levels of total KHSRP protein.
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human KHSRP protein. Antibodies are purified by protein A and peptide affinity chromatography.
KHSRP, also known as KSRP, is a KH domain-containing AU-rich element (ARE) binding protein (1). It recruits degradation machinery and activates mRNA turnover (2). This protein was previously shown to function as a regulator for splicing (3). KHSRP associates with both the Drosha and Dicer multiprotein complexes (4), and controls the biogenesis of some microRNAs by binding to the terminal loops of these microRNA precursors (3). KHSRP is found in neural and non-neural cell types in both the nucleus and the cytoplasm (4).
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For Research Use Only. Not For Use In Diagnostic Procedures.
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