Product Pathways - Translational Control
Ribosomal Protein L26 (D8F6) Rabbit mAb #5400
PhosphoSitePlus® protein, site, and accession data: RPL26
| Applications | Reactivity | Sensitivity | MW (kDa) | Isotype |
|---|---|---|---|---|
| W | H M R Mk | Endogenous | 17 | Rabbit IgG |
Applications Key:
W=Western Blotting
Reactivity Key:
H=Human
M=Mouse
R=Rat
Mk=Monkey
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
Protocols
- 5400:
- Western Blotting
Specificity / Sensitivity
Ribosomal Protein L26 (D8F6) Rabbit mAb detects endogenous levels of total ribosomal protein L26.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu38 of human ribosomal protein L26.
Western Blotting
Western blot analysis of extracts from various cell types using Ribosomal Protein L26 (D8F6) Rabbit mAb.
Background
Ribosomal protein L26 (RPL26) is a component of the 60S ribosomal subunit and is involved in translation (1,2). It was shown that RPL26 increases the translation of p53 mRNA by binding to its 5' untranslated region (UTR) after DNA damage. Studies found that overexpression of RPL26 enhances the binding of p53 mRNA to the ribosomes and increases p53 translation. Overexpression of RPL26 also induces cell-cycle arrest at G1 phase and increases radiation-stimulated apoptosis (2).
Application References
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- 9998 BSA
- 9999 Nonfat Dry Milk
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- 7074 Anti-rabbit IgG, HRP-linked Antibody
- 7720 Prestained Protein Marker, Broad Range (Premixed Format)
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For Research Use Only. Not For Use In Diagnostic Procedures.
