Product Pathways - Lymphocyte Signaling
Galectin-1/LGALS1 Antibody #5418
|W||H M R (Mk)||Endogenous||15||Rabbit|
Reactivity Key: H=Human M=Mouse R=Rat Mk=Monkey
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
Specificity / Sensitivity
Galectin-1/LGALS1 Antibody detects endogenous levels of total galectin-1 protein.
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu33 of human galectin-1 protein. Antibodies are purified by protein A and peptide affinity chromatography.
Galectins are a family of β-galactose binding proteins that are characterized by their affinity for poly-N-acetyllactosamine-enriched glycoconjugates and their carbohydrate-binding site (1,2). Members of the galectin family have been implicated in a variety of biological functions including cell adhesion (3), growth regulation (4), cytokine production (5), T-cell apoptosis (6), and immune responses (7). Galectin-1 (LGALS1) has been shown to be expressed in a wide range of tissues and cell types. The level and pattern of expression of galectin-1 has been shown to change during development (8). In addition to its apparent role in developmental processes, galectin-1 has been shown to be involved in central immune tolerance and may function in tumorigenesis by modulating the immune response to the tumor (9,10). Research studies have shown that galectin-1 expression is increased in several human cancers, suggesting a correlation with metastatic potential (10).
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- Filer, A. et al. (2009) Arthritis Rheum 60, 1604-14.
- Perillo, N.L. et al. (1995) Nature 378, 736-9.
- Cooper, D.N. et al. (1991) J Cell Biol 115, 1437-48.
- Puche, A.C. et al. (1996) Dev Biol 179, 274-87.
- van den Brûle, F. et al. (2003) Lab Invest 83, 377-86.
- Salatino, M. et al. (2008) Expert Opin Biol Ther 8, 45-57.
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For Research Use Only. Not For Use In Diagnostic Procedures.