Product Pathways - Growth Factors/Cytokines
IL-17RA Antibody #5503
Reactivity Key: H=Human
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
Specificity / Sensitivity
IL-17RA Antibody recognizes endogenous levels of total IL-17RA protein.
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val790 of human IL-17RA protein. Antibodies are purified by protein A and peptide affinity chromatography.
Western blot analysis of extracts from 293T cells, mock transfected (-) or transfected with a construct expressing Myc/DDK-tagged full-length human IL-17RA (hIL-17RA-Myc/DDK; +), using IL-17RA Antibody.
The IL-17 family of cytokines consists of IL-17A-F and their receptors include IL-17RA-RE (1). IL-17 cytokines are produced by a variety of cell types including the Th17 subset of CD4+ T cells, as well as subsets of γδ T cells, NK cells, and NKT cells (2). IL-17A and IL-17F, the most well-studied of the IL-17 cytokines, contribute to fungal and bacterial immunity by inducing expression of proinflammatory cytokines, chemokines, and antimicrobial peptides (2). In addition, IL-17A contributes to the pathogenesis of several autoimmune diseases (3). IL-17E promotes Th2 cell responses (4). The roles of IL-17B, IL-17C, and IL-17D are less clear, however these family members also appear to have the capacity to induce proinflammatory cytokines (1,5,6). IL-17 receptors have an extracellular domain, a transmembrane domain, and a SEFIR domain. They are believed to signal as homodimers, heterodimers, or multimers through their SEFIR domain by recruiting the SEFIR domain-containing adaptor Act1 (7). Unlike most cytokines that signal through Jak/STAT pathways, IL-17 signaling results in NF-κB activation (8).
IL-17RA associates with IL-17RC to mediate signaling by homodimers and heterodimers of IL-17A and IL-17F (9,10). IL-17RA is broadly expressed, with highest expression in hematopoietic cells (11).
- Gaffen, S.L. (2009) Nat Rev Immunol 9, 556-67.
- Iwakura, Y. et al. (2011) Immunity 34, 149-62.
- Hu, Y. et al. (2011) Ann N Y Acad Sci 1217, 60-76.
- Fort, M.M. et al. (2001) Immunity 15, 985-95.
- Yamaguchi, Y. et al. (2007) J Immunol 179, 7128-36.
- Li, H. et al. (2000) Proc Natl Acad Sci U S A 97, 773-8.
- Chang, S.H. et al. (2006) J Biol Chem 281, 35603-7.
- Shalom-Barak, T. et al. (1998) J Biol Chem 273, 27467-73.
- Toy, D. et al. (2006) J Immunol 177, 36-9.
- Wright, J.F. et al. (2008) J Immunol 181, 2799-805.
- Yao, Z. et al. (1995) Immunity 3, 811-21.
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For Research Use Only. Not For Use In Diagnostic Procedures.