Product Pathways - Tyrosine Kinase / Adaptors
DDR1 (D1G6) XP® Rabbit mAb #5583
|5583S||100 µl (10 western blots)||---||In Stock||---|
|5583P||40 µl (4 western blots)||---||In Stock||---|
|5583||carrier free and custom formulation / quantity||email request|
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|W||1:1000||Human, Mouse, Rat, Monkey||Endogenous||125||Rabbit IgG|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting, IP=Immunoprecipitation, IHC-P=Immunohistochemistry (Paraffin), IF-IC=Immunofluorescence (Immunocytochemistry)
Specificity / Sensitivity
DDR1 (D1G6) XP® Rabbit mAb detects endogeneous levels of total DDR1 protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro600 of human DDR1 protein.
Western blot analysis of extracts from MCF7 and C6 cell lines, and tissue from mouse brain using DDR1 (D1G6) XP® Rabbit mAb.
Immunohistochemical analysis of paraffin-embedded human colon carcinoma using DDR1 (D1G6) XP (TM) RmAb.
Immunohistochemical analysis of paraffin-embedded human lung carcinoma using DDR1 (D1G6) XP (TM) RmAb in the presence of control peptide (left) or antigen-specific peptide (right).
The discoidin domain receptors (DDRs) are receptor tyrosine kinases with a discoidin homology repeat in their extracellular domains, activated by binding to extracellular matrix collagens. So far, two mammalian DDRs have been identified: DDR1 and DDR2 (1). They are widely expressed in human tissues and may have roles in smooth muscle cell-mediated collagen remodeling (2). Research studies have implicated aberrant expression and signaling of DDRs in human diseases related to increased matrix degradation and remodeling, such as cardiovascular disease, liver fibrosis, and tumor invasion (1).
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For Research Use Only. Not For Use In Diagnostic Procedures.
XP® is a trademark of Cell Signaling Technology, Inc.
DRAQ5® is a registered trademark of Biostatus Limited.
Cell Signaling Technology® is a trademark of Cell Signaling Technology, Inc.