Product Pathways - Neuroscience
RAIG1 Antibody #5657
|5657S||100 µl (10 western blots)||---||In Stock||---|
|5657||carrier free and custom formulation / quantity||email request|
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Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting, IF-IC=Immunofluorescence (Immunocytochemistry)
Specificity / Sensitivity
RAIG1 Antibody recognizes endogenous levels of total RAIG1 protein.
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val295 of human RAIG1 protein. Antibodies are purified by protein A and peptide affinity chromatography.
Western blot analysis of extracts from untransfected or human RAIG1-transfected 293T cells and untransfected MKN-45 cells using RAIG1 Antibody.
Retinoic Acid-Induced Gene 1 (RAIG1), also called RAI3 and GPRC5A, belongs to the family of G protein-coupled receptors (GPCRs). GPCRs are the largest and most abundant receptor family in mammals, composed of more than one thousand members (1). Retinoic acids (RA) are a group of pleiotropic signaling molecules that regulate a broad range of physiologic and developmental processes. It is thought that RAIG1 may be a downstream target of RA signaling (2). RAIG1 is expressed in lung tissue and in several lung cancer cell lines, and encodes a seven-transmembrane glycoprotein presumed to be a lung tumor suppressor gene (3,4).
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