Product Pathways - Neuroscience
Musashi-1 (D46A8) XP® Rabbit mAb #5663
|5663S||100 µl (10 western blots)||---||In Stock||---|
|5663P||40 µl (4 western blots)||---||In Stock||---|
|5663||carrier free and custom formulation / quantity||email request|
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|W||1:1000||Human, Mouse, Rat||Endogenous||35||Rabbit IgG|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting, IF-F=Immunofluorescence (Frozen)
Specificity / Sensitivity
Musashi-1 (D46A8) XP® Rabbit mAb detects endogenous levels of total Musashi-1 protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Met190 of human Musashi-1 protein.
Western blot analysis of extracts from neonatal mouse brain and fetal rat brain using Musashi-1 (D46A8) XP® Rabbit mAb.
Western blot analysis of extracts from SH-SY5Y, NCCIT, and PC-3 cells using Musashi-1 (D46A8) XP® Rabbit mAb (upper) and α/β-Tubulin Antibody #2148 (lower).
Confocal immunofluorescent analysis of P4 rat brain using Musashi-1 (D46A8) XP® Rabbit mAb (green) and Nestin (Rat-401) Mouse mAb #4760 (red). Blue pseudocolor = DRAQ5® #4084 (fluorescent DNA dye).
Musashi-1 and Musashi-2 are RNA-binding proteins which play a role in asymmetric cell division of ectodermal precursor cells by regulating the translation of target mRNA. Both family members augment Notch signaling and repress the translation of m-Numb, a protein that positively modulates differentiation of neural stem cells into neurons. Thus, Musashi contributes to the maintenance of neural stem cells (1). While Musashi-1 is frequently used as a marker for proliferating neural precursor cells, it is also expressed in epithelial stem cells including intestinal and mammary gland stem cells (2-4).
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For Research Use Only. Not For Use In Diagnostic Procedures.
XP® is a trademark of Cell Signaling Technology, Inc.
DRAQ5® is a registered trademark of Biostatus Limited.
Cell Signaling Technology® is a trademark of Cell Signaling Technology, Inc.